Detection of tumor associated antigens in blood plasma of tumor bearing cattle and buffalo

–SDS – Polyacrylamide Gel Electrophoresis (SDS PAGE) of blood plasma from three cattle and one buffalo affected with various tumors (odontoma, nasal granuloma and horn cancer in cattle and teat tumor in buffalo) revealed the presence of new proteins p51, p53 and p71-72 in all the samples which were not present in plasma from normal healthy bovines. However, another protein, p77.5 present in normal plasma samples was absent in the plasma of only one (horn cancer affected) out of three tumor affected cows. The possibility of these proteins as markers of tumorigenesis is discussed. Keywords––Tumors, tumor associated antigens, differentiation antigens, cattle, buffalo.